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  Ventral striatal activation during reward processing in subjects with ultra-high risk for schizophrenia

Juckel, G., Friedel, E., Koslowski, M., Witthaus, A., Özgürdal, S., Gudlowski, Y., et al. (2012). Ventral striatal activation during reward processing in subjects with ultra-high risk for schizophrenia. Neuropsychobiology, 66(1), 50-56. doi:10.1159/000337130.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-69BC-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C204-D
Genre: Journal Article

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 Creators:
Juckel, G.1, 2, Author
Friedel, E.2, Author
Koslowski, M.2, Author
Witthaus, A.1, 2, Author
Özgürdal, S.1, 2, Author
Gudlowski, Y.2, Author
Knutson, B.3, Author
Wrase, J.2, Author
Brüne, M.1, Author
Heinz, A.2, Author
Schlagenhauf, Florian2, 4, Author              
Affiliations:
1Department of Psychiatry, Ruhr University, Bochum, Germany, ou_persistent22              
2Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department of Psychology, Stanford University, CA, USA, ou_persistent22              
4Max Planck Fellow Group Cognitive and Affective Control of Behavioural Adaptation, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1753350              

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Free keywords: Nucleus accumbens; Reward expectation; Functional magnetic resonance imaging; Prodrome; Schizophrenia
 Abstract: Background: Early dysfunction of the brain reward system in schizophrenia might be already recognized in the prodromal phase of this illness. We used functional magnetic resonance imaging to assess the blood oxygen level-dependent response in the ventral striatum (VS) of subjects with ultra-high risk for psychosis during the presentation of reward-indicating and loss-indicating stimuli. Methods: Thirteen prodromal patients (mean age: 25.5 ± 4.6 years) and 13 age-matched healthy volunteers participated in an incentive monetary delay task, in which visual cues predicted that a rapid response to a subsequent target stimulus will gain money, avoid losing money or have no consequence. Results: Compared with the neutral condition, anticipation of reward loss-avoidance elicited significant activation of the VS in both healthy subjects and subjects with ultra-high risk for psychosis, but there was only a statistical tendency for less activation during loss-avoidance anticipation in prodromal compared to healthy subjects. Discussion: This study provides a first weak hint, as revealed by functional magnetic resonance imaging, for impaired activation of a central area of the mesolimbic dopaminergic brain reward system, the VS, already in subjects with ultra-high risk for psychosis, which is in line with results of patients with full-blown schizophrenic psychosis. This pilot study has, however, strong limitations, and its results need to be replicated first before they can be used e.g. for early recognition of patients in the schizophrenic prodrome.

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Language(s): eng - English
 Dates: 2011-06-272011-12-122012-07-132012-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1159/000337130
PMID: 22797277
Other: Epub 2012
 Degree: -

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Title: Neuropsychobiology
Source Genre: Journal
 Creator(s):
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Publ. Info: Basel : Karger.
Pages: - Volume / Issue: 66 (1) Sequence Number: - Start / End Page: 50 - 56 Identifier: ISSN: 0302-282X
CoNE: https://pure.mpg.de/cone/journals/resource/954925510411