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  Context insensitivity during positive and negative emotional expectancy in depression assessed with functional magnetic resonance imaging

Feeser, M., Schlagenhauf, F., Sterzer, P., Park, S., Stoy, M., Gutwinski, S., et al. (2013). Context insensitivity during positive and negative emotional expectancy in depression assessed with functional magnetic resonance imaging. Psychiatry Research: Neuroimaging, 212(1), 28-35. doi:10.1016/j.pscychresns.2012.11.010.

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 Creators:
Feeser, Melanie1, 2, Author
Schlagenhauf, Florian1, 3, Author           
Sterzer, Philipp1, 4, Author
Park, Soyoung4, 5, Author
Stoy, Meline1, Author
Gutwinski, Stefan1, Author
Dalanay, Umut1, Author
Kienast, Thorsten1, Author
Bauere, Michael6, Author
Heinz, Andreas1, 5, Author
Ströhle, Andreas1, 4, Author
Bermpohl, Felix1, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Cluster Languages of Emotion, FU Berlin, Germany, ou_persistent22              
3Max Planck Fellow Group Cognitive and Affective Control of Behavioural Adaptation, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1753350              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              
6Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden, Germany, ou_persistent22              

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Free keywords: Major depressive disorder; Emotion; Anticipation; Functional magnetic resonance imaging (fMRI); Prefrontal cortex; Affective processing bias
 Abstract: Patients with depression show an enhanced preoccupation with negative expectations and are often unable to look forward to positive events. Here we studied anticipatory emotional processes in unmedicated depressed patients using functional magnetic resonance imaging. Consistent with a negative processing bias, we hypothesized enhanced responses to negative and attenuated responses to positive expectancy cues in brain areas associated with emotional expectancy. Participants comprised 19 drug-free depressed patients and 19 matched healthy control subjects who viewed affective photographs. Pictures were preceded by an expectancy cue which signaled the emotional valence of the upcoming picture in half of the trials. Depressed patients showed attenuated blood-oxygen-level-dependent responses in the left lateral prefrontal cortex (inferior frontal gyrus, Brodmann area 44) during positive expectancy and—contrary to our hypothesis—in the right lateral orbitofrontal cortex (middle frontal gyrus, Brodmann area 47) during negative expectancy. This attenuation was specific for the anticipation (as opposed to the perception) of emotional pictures and correlated with a clinical measure of depressive symptoms. The observed attenuation suggests emotion-context insensitivity rather than a negative processing bias during anticipatory emotional processes in depression. This hyporeactivity may contribute to clinical features like anergia, apathy, and loss of motivation in the context of both positive and negative incentives.

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Language(s): eng - English
 Dates: 2012-11-052012-03-082012-11-162013-03-052013-04-30
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.pscychresns.2012.11.010
PMID: 23473989
Other: Epub 2013
 Degree: -

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Title: Psychiatry Research: Neuroimaging
  Other : Psychiatry Res. Neuroimaging
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 212 (1) Sequence Number: - Start / End Page: 28 - 35 Identifier: ISSN: 0925-4927
CoNE: https://pure.mpg.de/cone/journals/resource/954925566740