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  Decline in prefrontal catecholamine synthesis explains age-related changes in cognitive speed beyond regional grey matter atrophy

Kalbitzer, J., Deserno, L., Schlagenhauf, F., Beck, A., Mell, T., Bahr, G., et al. (2012). Decline in prefrontal catecholamine synthesis explains age-related changes in cognitive speed beyond regional grey matter atrophy. European Journal of Nuclear Medicine and Molecular Imaging, 39(9), 1462-1466. doi:10.1007/s00259-012-2162-4.

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 Creators:
Kalbitzer, Jan1, Author
Deserno, Lorenz1, Author              
Schlagenhauf, Florian1, Author              
Beck, Anne1, Author
Mell, Thomas1, Author
Bahr, Gerd1, Author
Buchholz, Hans-Georg2, Author
Plotkin, Michail3, Author
Buchert, Ralph3, Author
Kumakura, Yoshitaka4, Author
Cumming, Paul5, Author
Heinz, Andreas1, 6, Author
Rapp, Michael A.1, 7, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Nuclear Medicine, Johannes Gutenberg University, Mainz, Germany, ou_persistent22              
3Department of Nuclear Medicine, Charité University Medicine Berlin, Germany, ou_persistent22              
4Ministry of Health, Labour and Welfare, Kanto Rosai Hospital, Kawasaki, Japan, ou_persistent22              
5Department of Nuclear Medicine, Ludwig Maximilians University Munich, Germany, ou_persistent22              
6NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
7Icahn School of Medicine at Mount Sinai, New York, NY, USA, ou_persistent22              

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Free keywords: Ageing; Biological parametric mapping; Cognitive speed; Dopamine
 Abstract: Purpose Age-related decline in cognitive speed has been associated with prefrontal dopamine D1 receptor availability, but the contribution of presynaptic dopamine and noradrenaline innervation to age-related changes in cognition is unknown. Methods In a group of 16 healthy participants aged 22–61 years, we used PET and the radioligand FDOPA to measure catecholamine synthesis capacity (K in app; millilitres per gram per minute) and the digit symbol substitution test to measure cognitive speed, a component of fluid IQ. Results Cognitive speed was associated with the magnitude of K in app in the prefrontal cortex (p < 0.0005). Both cognitive speed (p = 0.003) and FDOPA K in app (p < 0.0005) declined with age, both in a standard voxel-wise analysis and in a volume-of-interest analysis with partial volume correction, and the correlation between cognitive speed and K in app remained significant beyond the effects of age (p = 0.047). MR-based segmentation revealed that these age-related declines were not attributable to age-related alterations in grey matter density. Conclusion Our findings indicate that age-related changes in the capacity of the prefrontal cortex to synthesize catecholamines, irrespective of cortical atrophy, may underlie age-related decline in cognitive speed.

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Language(s): eng - English
 Dates: 2011-12-212012-05-182012-06-192012-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s00259-012-2162-4
PMID: 22710957
Other: Epub 2012
 Degree: -

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Title: European Journal of Nuclear Medicine and Molecular Imaging
  Other : Eur. J. Nucl. Med. Mol. Imaging
Source Genre: Journal
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Publ. Info: Heidelberg, Germany : Springer-Verlag
Pages: - Volume / Issue: 39 (9) Sequence Number: - Start / End Page: 1462 - 1466 Identifier: ISSN: 1619-7070
CoNE: https://pure.mpg.de/cone/journals/resource/954925519624