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  Chemoenzymatic synthesis of a characteristic phosphopeptide fragment of the Raf-1 kinase

Sebastian, D., & Waldmann, H. (1997). Chemoenzymatic synthesis of a characteristic phosphopeptide fragment of the Raf-1 kinase. TETRAHEDRON LETTERS, 38(17), 2927-2930. doi:10.1016/S0040-4039(97)00514-5.

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 Creators:
Sebastian, D1, Author
Waldmann, Herbert2, Author           
Affiliations:
1external, ou_persistent22              
2Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753290              

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Free keywords: SOLID-PHASE SYNTHESIS; PHOSPHOTYROSYL PEPTIDE; PROTECTING GROUPS; PHOSPHORYLATION; PROTEIN; SERINE; RECEPTOR; SIGNAL; RAS
 Abstract: Base-labile biologically relevant phosphopeptides can advantageously be synthesized under very mild conditions (pH 7, 37 degrees C) by employing the heptyl (Hep) ester as enzyme-labile protecting group. This method was used in the construction of a characteristic, selectively phosphorylated hydroxyamino acid fragment of the Raf-l kinase, an important constituent of the Ras pathway of signal transduction. (C) 1997 Elsevier Science Ltd.

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Language(s): eng - English
 Dates: 1997
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: TETRAHEDRON LETTERS
Source Genre: Journal
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Publ. Info: KIDLINGTON, OXFORD : PERGAMON-ELSEVIER SCIENCE
Pages: - Volume / Issue: 38 (17) Sequence Number: - Start / End Page: 2927 - 2930 Identifier: ISSN: 0040-4039