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  Selective enzymatic removal of protecting groups: The phenylacetamide as amino protecting group in phosphopeptide synthesis

Waldmann, H., Heuser, A., & Schulze, S. (1996). Selective enzymatic removal of protecting groups: The phenylacetamide as amino protecting group in phosphopeptide synthesis. TETRAHEDRON LETTERS, 37(48), 8725-8728. doi:10.1016/S0040-4039(96)02041-2.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-71F3-9 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-726B-4
Genre: Journal Article

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 Creators:
Waldmann, Herbert1, Author           
Heuser, A2, Author
Schulze, S2, Author
Affiliations:
1Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753290              
2external, ou_persistent22              

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Free keywords: SOLID-PHASE SYNTHESIS; PHOSPHOTYROSYL PEPTIDE; PHOSPHORYLATION; PROTEIN; SIGNAL; PHOSPHATASES; NUCLEOSIDES; RECEPTOR; SERINE
 Abstract: The phenylacetamido (PhAc) amino protecting group can be removed from sensitive phosphopeptides by means of penicillin G acylase under mild conditions (pH 6.5, room temperature) and without attack on the peptide bonds, the C-terminal esters or the phosphates. In particular, under the conditions of the enzymatic reactions a beta-elimination of the phosphate does not occur. Copyright (C) 1996 Elsevier Science Ltd

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Language(s): eng - English
 Dates: 1996
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: A1996VV09700028
DOI: 10.1016/S0040-4039(96)02041-2
 Degree: -

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Title: TETRAHEDRON LETTERS
Source Genre: Journal
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Affiliations:
Publ. Info: KIDLINGTON, OXFORD : PERGAMON-ELSEVIER SCIENCE
Pages: - Volume / Issue: 37 (48) Sequence Number: - Start / End Page: 8725 - 8728 Identifier: ISSN: 0040-4039