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キーワード:
SOLID-PHASE SYNTHESIS; PHOSPHOTYROSYL PEPTIDE; PHOSPHORYLATION; PROTEIN; SIGNAL; PHOSPHATASES; NUCLEOSIDES; RECEPTOR; SERINE
要旨:
The phenylacetamido (PhAc) amino protecting group can be removed from sensitive phosphopeptides by means of penicillin G acylase under mild conditions (pH 6.5, room temperature) and without attack on the peptide bonds, the C-terminal esters or the phosphates. In particular, under the conditions of the enzymatic reactions a beta-elimination of the phosphate does not occur. Copyright (C) 1996 Elsevier Science Ltd
