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Free keywords:
PEN-G ACYLASE; CATALYZED-HYDROLYSIS; PHENYLACETATE ESTERS; RESOLUTION; ASPARTAME
Abstract:
The efficiency of penicillin G acylase catalyzed transformations is enhanced significantly with respect to reaction velocity, and in particular, stereoselectivity by appropriate ''substrate tuning'', i.e. by the introduction of a nitrogen atom into the part of the substrates which is recognized by the enzyme.