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  Twisted signatures of GC-biased gene conversion embedded in an evolutionary stable karyotype

Mugal, C. F., Arndt, P. F., & Ellegren, H. (2013). Twisted signatures of GC-biased gene conversion embedded in an evolutionary stable karyotype. Molecular Biology and Evolution, 30(7), 1700-1712. doi:10.1093/molbev/mst067.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-7C01-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-7C06-B
Genre: Journal Article

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© 2013 Society for Molecular Biology and Evolution
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Mugal, Carina F.1, Author
Arndt, Peter F.2, Author              
Ellegren, Hans1, Author
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1Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University , Uppsala, Sweden , ou_persistent22              
2Evolutionary Genomics (Peter Arndt), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, Berlin, Germany, ou_1479638              

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 Abstract: The genomes of many vertebrates show a characteristic heterogeneous distribution of GC content, the so-called GC isochore structure. The origin of isochores has been explained via the mechanism of GC-biased gene conversion (gBGC). However, although the isochore structure is declining in many mammalian genomes, the heterogeneity in GC content is being reinforced in the avian genome. Despite this discrepancy, which remains unexplained, examinations of individual substitution frequencies in mammals and birds are both consistent with the gBGC model of isochore evolution. On the other hand, a negative correlation between substitution and recombination rate found in the chicken genome is inconsistent with the gBGC model. It should therefore be important to consider along with gBGC other consequences of recombination on the origin and fate of mutations, as well as to account for relationships between recombination rate and other genomic features. We therefore developed an analytical model to describe the substitution patterns found in the chicken genome, and further investigated the relationships between substitution patterns and several genomic features in a rigorous statistical framework. Our analysis indicates that GC content itself, either directly or indirectly via interrelations to other genomic features, has an impact on the substitution pattern. Further, we suggest that this phenomenon is particularly visible in avian genomes due to their unusually low rate of chromosomal evolution. Because of this, interrelations between GC content and other genomic features are being reinforced, and are as such more pronounced in avian genomes as compared with other vertebrate genomes with a less stable karyotype.

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Language(s): eng - English
 Dates: 2013-04-052013-07
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1093/molbev/mst067
ISSN: 1537-1719 (Electronic)0737-4038 (Print)
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Title: Molecular Biology and Evolution
  Other : Mol. Biol. Evol.
Source Genre: Journal
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Publ. Info: Chicago, Ill. : University of Chicago Press
Pages: - Volume / Issue: 30 (7) Sequence Number: - Start / End Page: 1700 - 1712 Identifier: ISSN: 0737-4038
CoNE: /journals/resource/954925536119