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  Meiotic Recombination Strongly Influences GC-Content Evolution in Short Regions in the Mouse Genome

Clement, Y., & Arndt, P. F. (2013). Meiotic Recombination Strongly Influences GC-Content Evolution in Short Regions in the Mouse Genome. Molecular Biology and Evolution. doi:10.1093/molbev/mst154.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-7C47-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-7C48-6
Genre: Journal Article

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Clément et al.pdf (Publisher version), 261KB
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© 2013 Society for Molecular Biology and Evolution
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 Creators:
Clement, Y.1, Author
Arndt, P. F.1, Author
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1Max Planck Society, ou_persistent13              

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 Abstract: Meiotic recombination is known to influence GC-content evolution in large regions of mammalian genomes by favoring the fixation of G and C alleles and increasing the rate of A/T to G/C substitutions. This process is known as GC-biased gene conversion (gBGC). Until recently, genome-wide measures of fine-scale recombination activity were unavailable in mice. Additionally, comparative studies focusing on mouse were limited as the closest organism with its genome fully sequenced was rat. Here, we make use of the recent mapping of double strand breaks (DSBs), the first step of meiotic recombination, in the mouse genome and of the sequencing of mouse closely related subspecies to analyze the fine-scale evolutionary signature of meiotic recombination on GC-content evolution in recombination hotspots, short regions that undergo extreme rates of recombination. We measure substitution rates around DSB hotspots and observe that gBGC is affecting a very short region ( approximately 1 kbp) in length around these hotspots. Furthermore, we can infer that the locations of hotspots evolved rapidly during mouse evolution.

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Language(s): eng - English
 Dates: 2013-10-26
 Publication Status: Published online
 Pages: -
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 Rev. Method: Peer
 Identifiers: DOI: 10.1093/molbev/mst154
ISSN: 1537-1719 (Electronic)0737-4038 (Print)
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Title: Molecular Biology and Evolution
  Other : Mol. Biol. Evol.
Source Genre: Journal
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Publ. Info: Chicago, Ill. : University of Chicago Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0737-4038
CoNE: /journals/resource/954925536119