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  The RNA exosome and proteasome: common principles of degradation control

Makino, D. L., Halbach, F., & Conti, E. (2013). The RNA exosome and proteasome: common principles of degradation control. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 14(10), 654-660. doi:10.1038/nrm3657.

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 Creators:
Makino, Debora L.1, Author           
Halbach, Felix1, Author           
Conti, Elena1, Author           
Affiliations:
1Conti, Elena / Structural Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565144              

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Free keywords: HUMAN PM-SCL; NF-KAPPA-B; 26S PROTEASOME; RIBOSOMAL-RNA; 20S PROTEASOMES; YEAST EXOSOME; POLY(A) POLYMERASE; CRYSTAL-STRUCTURE; QUALITY-CONTROL; MULTICATALYTIC PROTEASE
 Abstract: Defective RNAs and proteins are swiftly degraded by cellular quality control mechanisms. A large fraction of their degradation is mediated by the exosome and the proteasome. These complexes have a similar architectural framework based on cylindrical, hollow structures that are conserved from bacteria and archaea to eukaryotes. Mechanistic similarities have also been identified for how RNAs and proteins are channelled into these structures and prepared for degradation. Insights gained from studies of the proteasome should now set the stage for elucidating the regulation, assembly and small-molecule inhibition of the exosome.

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Language(s): eng - English
 Dates: 2013-10
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000324810500014
DOI: 10.1038/nrm3657
 Degree: -

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Title: NATURE REVIEWS MOLECULAR CELL BIOLOGY
Source Genre: Journal
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Publ. Info: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Pages: - Volume / Issue: 14 (10) Sequence Number: - Start / End Page: 654 - 660 Identifier: ISSN: 1471-0072