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  Impact of image acquisition on voxel-based morphometry investigations of age-related structural brain changes

Streitbürger, D. P., Pampel, A., Krueger, G., Lepsien, J., Schroeter, M. L., Mueller, K., et al. (2014). Impact of image acquisition on voxel-based morphometry investigations of age-related structural brain changes. NeuroImage, 87, 170-182. doi:10.1016/j.neuroimage.2013.10.051.

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Streitbürger, Daniel Paolo1, Autor           
Pampel, André1, Autor           
Krueger, Gunnar2, Autor
Lepsien, Jöran1, Autor           
Schroeter, Matthias L.3, Autor           
Mueller, Karsten1, Autor           
Möller, Harald E.1, Autor           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Siemens Schweiz AG, Healthcare Sector IM & WS, Renens, Switzerland, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Schlagwörter: Aging; Imaging pulse sequence; Radiofrequency coil; Voxel size; Voxel-based morphometry
 Zusammenfassung: A growing number of magnetic resonance imaging studies employ voxel-based morphometry (VBM) to assess structural brain changes. Recent reports have shown that image acquisition parameters may influence VBM results. For systematic evaluation, gray-matter-density (GMD) changes associated with aging were investigated by VBM employing acquisitions with different radiofrequency head coils (12-channel matrix coil vs. 32-channel array), different pulse sequences (MP-RAGE vs. MP2RAGE), and different voxel dimensions (1 mm vs. 0.8 mm). Thirty-six healthy subjects, classified as young, middle-aged, or elderly, participated in the study. Two-sample and paired t-tests revealed significant effects of acquisition parameters (coil, pulse sequence, and resolution) on the estimated age-related GMD changes in cortical and subcortical regions. Potential advantages in tissue classification and segmentation were obtained for MP2RAGE. The 32-channel coil generally outperformed the 12-channel coil, with more benefit for MP2RAGE. Further improvement can be expected from higher resolution if the loss in SNR is accounted for. Use of inconsistent acquisition parameters in VBM analyses is likely to introduce systematic bias. Overall, acquisition and protocol changes require careful adaptations of the VBM analysis strategy before generalized conclusion can be drawn.

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Sprache(n): eng - English
 Datum: 2013-10-242013-11-022014-02-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuroimage.2013.10.051
PMID: 24188812
Anderer: Epub 2013
 Art des Abschluß: -

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 87 Artikelnummer: - Start- / Endseite: 170 - 182 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166