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  Relationship between imaging biomarkers, age, progression and symptom severity in Alzheimer's disease

Dukart, J., Mueller, K., Villringer, A., Kherif, F., Draganski, B., Frackowiak, R., et al. (2013). Relationship between imaging biomarkers, age, progression and symptom severity in Alzheimer's disease. NeuroImage: Clinical, 3, 84-94. doi:10.1016/j.nicl.2013.07.005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-79AD-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-841C-9
Genre: Journal Article

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 Creators:
Dukart, Jürgen1, 2, 3, 4, Author              
Mueller, Karsten5, Author              
Villringer, Arno1, 3, 6, Author              
Kherif, Ferath2, Author
Draganski, Bogdan2, Author              
Frackowiak, Richard2, Author
Schroeter, Matthias L.1, 3, 6, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
6Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Ageing; Alzheimer's disease; [18F]fluorodeoxyglucose positron emission tomography (FDG-PET); Magnetic resonance imaging (MRI); Mild cognitive impairment
 Abstract: The early diagnostic value of glucose hypometabolism and atrophy as potential neuroimaging biomarkers of mild cognitive impairment (MCI) and Alzheimer's disease (AD) have been extensively explored using [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) and structural magnetic resonance imaging (MRI). The vast majority of previous imaging studies neglected the effects of single factors, such as age, symptom severity or time to conversion in MCI thus limiting generalisability of results across studies. Here, we investigated the impact of these factors on metabolic and structural differences. FDG-PET and MRI data from AD patients (n = 80), MCI converters (n = 65) and MCI non-converters (n = 64) were compared to data of healthy subjects (n = 79). All patient groups were split into subgroups by age, time to conversion (for MCI), or symptom severity and compared to the control group. AD patients showed a strongly age-dependent pattern, with younger patients showing significantly more extensive reductions in gray matter volume and glucose utilisation. In the MCI converter group, the amount of glucose utilisation reduction was linked to the time to conversion but not to atrophy. Our findings indicate that FDG-PET might be more closely linked to future cognitive decline whilst MRI being more closely related to the current cognitive state reflects potentially irreversible damage.

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Language(s): eng - English
 Dates: 2013-07-032013-04-302013-07-212013-07-26
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.nicl.2013.07.005
PMID: 24179852
PMC: PMC3791277
Other: eCollection 2013
 Degree: -

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Title: NeuroImage: Clinical
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 3 Sequence Number: - Start / End Page: 84 - 94 Identifier: ISSN: 2213-1582
CoNE: /journals/resource/2213-1582