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  Neural correlates of the DemTect in Alzheimer's disease and frontotemporal lobar degeneration: A combined MRI & FDG-PET study

Woost, T. B., Dukart, J., Frisch, S., Barthel, H., Sabri, O., Müller, K., et al. (2013). Neural correlates of the DemTect in Alzheimer's disease and frontotemporal lobar degeneration: A combined MRI & FDG-PET study. NeuroImage: Clinical, 2, 746-758. doi:10.1016/j.nicl.2013.05.008.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-79B8-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-83E3-8
Genre: Journal Article

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 Creators:
Woost, Timo B.1, 2, Author
Dukart, Jürgen1, 3, 4, Author              
Frisch, Stefan1, 5, Author              
Barthel, Henryk3, 6, Author
Sabri, Osama3, 6, Author
Müller, Karsten7, Author              
Schroeter, Matthias L.1, 2, 3, 8, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
5Department of Neurology, Goethe University, Frankfurt, Germany, ou_persistent22              
6Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
7Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
8Consortium for Frontotemporal Lobar Degeneration, Leipzig, Germany, ou_persistent22              

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Free keywords: Alzheimer's disease; DemTect; FDG-PET; Frontotemporal lobar degeneration; MRI; Voxel based morphometry
 Abstract: Valid screening devices are critical for an early diagnosis of dementia. The DemTect is such an internationally accepted tool. We aimed to characterize the neural networks associated with performance on the DemTect's subtests in two frequent dementia syndromes: early Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). Voxel-based group comparisons of cerebral glucose utilization (as measured by F-18-fluorodeoxyglucose positron emission tomography) and gray matter atrophy (as measured by structural magnetic resonance imaging) were performed on data from 48 subjects with AD (n = 21), FTLD (n = 14) or subjective cognitive impairment (n = 13) as a control group. We performed group comparisons and correlation analyses between multimodal imaging data and performance on the DemTect's subtests. Group comparisons showed regional patterns consistent with previous findings for AD and FTLD. Interestingly, atrophy dominated in FTLD, whereas hypometabolism in AD. Across diagnostic groups performance on the “wordlist” subtest was positively correlated with glucose metabolism in the left temporal lobe. The “number transcoding” subtest was significantly associated with glucose metabolism in both a predominantly left lateralized frontotemporal network and a parietooccipital network including parts of the basal ganglia. Moreover, this subtest was associated with gray matter density in an extensive network including frontal, temporal, parietal and occipital areas. No significant correlates were observed for the “supermarket task” subtest. Scores on the “digit span reverse” subtest correlated with glucose metabolism in the left frontal cortex, the bilateral putamen, the head of caudate nucleus and the anterior insula. Disease-specific correlation analyses could partly verify or extend the correlates shown in the analyses across diagnostic groups. Correlates of gray matter density were found in FTLD for the “number transcoding” subtest and the “digit span reverse” subtest. Correlates of glucose metabolism were found in AD for the “wordlist” subtest and in FTLD for the “digit span reverse” subtest. Our study contributes to the understanding of the neural correlates of cognitive deficits in AD and FTLD and supports an external validation of the DemTect providing preliminary conclusions about disease-specific correlates.

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Language(s): eng - English
 Dates: 2013-05-082012-12-122013-05-142013-05-27
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.nicl.2013.05.008
PMID: 24179826
PMC: PMC3777755
Other: eCollection 2013
 Degree: -

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Title: NeuroImage: Clinical
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 2 Sequence Number: - Start / End Page: 746 - 758 Identifier: ISSN: 2213-1582
CoNE: /journals/resource/2213-1582