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  Suspended microchannel resonators for ultralow volume universal detection.

Son, S., Grover, W. H., Burg, T. P., & Manalis, S. R. (2008). Suspended microchannel resonators for ultralow volume universal detection. Analytical Chemistry, 80(12), 4757-4760. doi:10.1021/ac800307a.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-9C3A-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-2F82-3
Genre: Journal Article

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1851218.pdf (Publisher version), 356KB
 
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http://pubs.acs.org/doi/pdf/10.1021/ac800307a (Publisher version)
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 Creators:
Son, S., Author
Grover, W. H., Author
Burg, T. P.1, Author              
Manalis, S. R., Author
Affiliations:
1Research Group of Biological Micro- and Nanotechnology, MPI for biophysical chemistry, Max Planck Society, ou_578602              

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 Abstract: Universal detectors that maintain high sensitivity as the detection volume is reduced to the subnanoliter scale can enhance the utility of miniaturized total analysis systems (μ-TAS). Here the unique scaling properties of the suspended microchannel resonator (SMR) are exploited to show universal detection in a 10 pL analysis volume with a density detection limit of 1 µg/cm3 (10 Hz bandwidth) and a dynamic range of 6 decades. Analytes with low UV extinction coefficients such as polyethylene glycol (PEG) 8 kDa, glucose, and glycine are measured with molar detection limits of 0.66, 13.5, and 31.6 µM, respectively. To demonstrate the potential for real-time monitoring, gel filtration chromatography was used to separate different molecular weights of PEG as the SMR acquired a chromatogram by measuring the eluate density. This work suggests that the SMR could offer a simple and sensitive universal detector for various separation systems from liquid chromatography to capillary electrophoresis. Moreover, since the SMR is itself a microfluidic channel, it can be directly integrated into μ-TAS without compromising overall performance.

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Language(s): eng - English
 Dates: 2008-05-202008
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1021/ac800307a
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Title: Analytical Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 80 (12) Sequence Number: - Start / End Page: 4757 - 4760 Identifier: -