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  Suspended microchannel resonators for ultralow volume universal detection.

Son, S., Grover, W. H., Burg, T. P., & Manalis, S. R. (2008). Suspended microchannel resonators for ultralow volume universal detection. Analytical Chemistry, 80(12), 4757-4760. doi:10.1021/ac800307a.

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 Urheber:
Son, S., Autor
Grover, W. H., Autor
Burg, T. P.1, Autor           
Manalis, S. R., Autor
Affiliations:
1Research Group of Biological Micro- and Nanotechnology, MPI for biophysical chemistry, Max Planck Society, ou_578602              

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 Zusammenfassung: Universal detectors that maintain high sensitivity as the detection volume is reduced to the subnanoliter scale can enhance the utility of miniaturized total analysis systems (μ-TAS). Here the unique scaling properties of the suspended microchannel resonator (SMR) are exploited to show universal detection in a 10 pL analysis volume with a density detection limit of 1 µg/cm3 (10 Hz bandwidth) and a dynamic range of 6 decades. Analytes with low UV extinction coefficients such as polyethylene glycol (PEG) 8 kDa, glucose, and glycine are measured with molar detection limits of 0.66, 13.5, and 31.6 µM, respectively. To demonstrate the potential for real-time monitoring, gel filtration chromatography was used to separate different molecular weights of PEG as the SMR acquired a chromatogram by measuring the eluate density. This work suggests that the SMR could offer a simple and sensitive universal detector for various separation systems from liquid chromatography to capillary electrophoresis. Moreover, since the SMR is itself a microfluidic channel, it can be directly integrated into μ-TAS without compromising overall performance.

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Sprache(n): eng - English
 Datum: 2008-05-202008
 Publikationsstatus: Erschienen
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1021/ac800307a
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Titel: Analytical Chemistry
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 80 (12) Artikelnummer: - Start- / Endseite: 4757 - 4760 Identifikator: -