English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Suspended microchannel resonators for biomolecular detection.

Burg, T. P., & Manalis, S. R. (2003). Suspended microchannel resonators for biomolecular detection. Applied Physics Letters, 83(13), 2698-2700. doi:10.1063/1.1611625.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-9CE1-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C4F5-D
Genre: Journal Article

Files

show Files
hide Files
:
1851311.pdf (Publisher version), 512KB
 
File Permalink:
-
Name:
1851311.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute), MBPC; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Burg, T. P.1, Author              
Manalis, S. R., Author
Affiliations:
1Research Group of Biological Micro- and Nanotechnology, MPI for biophysical chemistry, Max Planck Society, ou_578602              

Content

show
hide
Free keywords: -
 Abstract: We present a resonant mass sensor for specific biomolecular detection in a subnanoliter fluid volume. The sensing principle is based on measuring shifts in resonance frequency of a suspended microfluidic channel upon accumulation of molecules on the inside walls of the device. Confining the fluid to the inside of a hollow cantilever enables direct integration with conventional microfluidic systems, significantly increases sensitivity by eliminating high damping and viscous drag, and allows the resonator to be actuated by electrostatic forces. Fluid density measurements reveal a mass resolution of 10−17 g/μm2 in a 4 mHz–4 Hz bandwidth. To demonstrate biomolecular detection, we present real-time measurements of the specific binding between avidin and biotinylated bovine serum albumin. Based on these measurements, we expect that changes in surface mass loading on the order of 10−19 g/μm2 can be detected in an optimized system.

Details

show
hide
Language(s): eng - English
 Dates: 2003
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1063/1.1611625
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Applied Physics Letters
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: 3 Volume / Issue: 83 (13) Sequence Number: - Start / End Page: 2698 - 2700 Identifier: -