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  Microfabricated mechanical biosensor with inherently differential readout.

Savran, C. A., Burg, T. P., Fritz, J., & Manalis, S. R. (2003). Microfabricated mechanical biosensor with inherently differential readout. Applied Physics Letters, 83(8), 1659-1661. doi:10.1063/1.1605238.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-9CFA-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C4F3-2
Genre: Journal Article

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1851314.pdf (Publisher version), 464KB
 
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 Creators:
Savran, C. A., Author
Burg, T. P.1, Author              
Fritz, J., Author
Manalis, S. R., Author
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1Research Group of Biological Micro- and Nanotechnology, MPI for biophysical chemistry, Max Planck Society, ou_578602              

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 Abstract: We report measurements with a micromachined mechanical biosensor that inherently suppresses background effects by producing a differential signal with respect to a reference. The sensor comprises two adjacent cantilevers with interdigitated fingers between them that allow interferometric detection of the differential, i.e., relative bending. We demonstrate that differential detection can efficiently suppress unspecific chemical effects that result in cantilever bending. We show that the differential deflection noise is up to an order of magnitude lower than the absolute deflection noise in the low-frequency range of 0.0003–1 Hz, where many types of biologically relevant reactions occur. We also demonstrate the sensor’s applicability to biological receptor–ligand systems by reporting experimental results on direct differential detection of biotin–streptavidin binding.

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Language(s): eng - English
 Dates: 2003
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1063/1.1605238
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Title: Applied Physics Letters
Source Genre: Journal
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Pages: - Volume / Issue: 83 (8) Sequence Number: - Start / End Page: 1659 - 1661 Identifier: -