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  Versatile Access to Chiral Indolines by Catalytic Asymmetric Fischer Indolization

Martínez, A., Webber, M. J., Müller, S., & List, B. (2013). Versatile Access to Chiral Indolines by Catalytic Asymmetric Fischer Indolization. Angewandte Chemie International Edition, 52(36), 9486-9490. doi:10.1002/anie.201301618.

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 Creators:
Martínez, Alberto1, Author              
Webber, Matthew J.1, Author              
Müller, Steffen1, Author              
List, Benjamin1, Author              
Affiliations:
1Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, ou_1445585              

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Free keywords: Brønsted acid catalysis; Fischer indole synthesis; heterocycles; indoline; organocatalysis
 Abstract: “Fisching” for complexity: The chiral Brønsted acid (R)‐STRIP catalyzes the asymmetric Fischer indolization of a range of monosubstituted cyclopentanones and cyclohexanones to give chiral fused indolines bearing a quaternary stereogenic center at the 3‐position. The method has been extended to include substrates bearing a tethered nucleophile, thus allowing for enantioselective indolization/ring‐closing cascades to complex propellanes featuring two vicinal quaternary stereocenters.

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Language(s): eng - English
 Dates: 2013-02-252013-04-292013-09-02
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201301618
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 52 (36) Sequence Number: - Start / End Page: 9486 - 9490 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851