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  Genome-wide mapping of gene–microbiota interactions in susceptibility to autoimmune skin blistering

Srinivas, G., Möller, S., Wang, J., Künzel, S., Zillikens, D., Baines, J. F., et al. (2013). Genome-wide mapping of gene–microbiota interactions in susceptibility to autoimmune skin blistering. Nature Communications, 4: 2462. doi:10.1038/ncomms3462.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-AADE-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-111A-4
Genre: Journal Article

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https://www.nature.com/articles/ncomms3462 (Publisher version)
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 Creators:
Srinivas, Girish1, Author              
Möller, Steffen, Author
Wang, Jun1, Author              
Künzel, Sven2, Author              
Zillikens, Detlef, Author
Baines, John F.1, Author              
Ibrahim, Saleh M., Author
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              
2Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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 Abstract: Susceptibility to chronic inflammatory diseases is determined by immunogenetic and environmental risk factors. Resident microbial communities often differ between healthy and diseased states, but whether these differences are of primary aetiological importance or secondary to the altered inflammatory environment remains largely unknown. Here we provide evidence for host gene–microbiota interactions contributing to disease risk in a mouse model of epidermolysis bullosa acquisita, an autoantibody-induced inflammatory skin disease. Using an advanced intercross, we identify genetic loci contributing to skin microbiota variability, susceptibility to skin blistering and their overlap. Furthermore, by treating bacterial species abundances as covariates with disease we reveal a novel disease locus. The majority of the identified covariate taxa are characterized by reduced abundance being associated with increased disease risk, providing evidence of a primary role in protection from disease. Further characterization of these putative probiotic species or species assemblages offers promising potential for preventative and therapeutic treatment development.

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Language(s): eng - English
 Dates: 2013-05-152013-08-192013-09-17
 Publication Status: Published online
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 Identifiers: DOI: 10.1038/ncomms3462
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 4 Sequence Number: 2462 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: /journals/resource/2041-1723