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  Functional Characterization of Human Genes from Exon Expression and RNA Interference Results

Emig, D., Blankenburg, H., Ramírez, F., & Albrecht, M. (2012). Functional Characterization of Human Genes from Exon Expression and RNA Interference Results. In R. S. Larson (Ed.), Bioinformatics and Drug Discovery (pp. 33-53). New York, NY: Humana Press.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0014-C529-0 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-B474-E
Genre: Buchkapitel
Latex : Functional Characterization of Human Genes from Exon Expression and {RNA} Interference Results

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 Urheber:
Emig, Dorothea1, Autor           
Blankenburg, Hagen1, Autor           
Ramírez, Fidel2, Autor
Albrecht, Mario1, Autor           
Affiliations:
1Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society, ou_40046              
2External Organizations, ou_persistent22              

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Schlagwörter: -
 Zusammenfassung: Complex biological systems comprise a large number of interacting molecules. The identification and detailed characterization of the functions of the involved genes and proteins are crucial for modeling and understanding such systems. To interrogate the various cellular processes, high-throughput techniques such as the Affymetrix Exon Array or RNA interference (RNAi) screens are powerful experimental approaches for functional genomics. However, they typically yield long gene lists that require computational methods to further analyze and functionally annotate the experimental results and to gain more insight into important molecular interactions. Here, we focus on bioinformatics software tools for the functional interpretation of exon expression data to discover alternative splicing events and their impact on gene and protein architecture, molecular networks, and pathways. We additionally demonstrate how to explore large lists of candidate genes as they also result from RNAi screens. In particular, our exemplary application studies show how to analyze the function of human genes that play a major role in human stem cells or viral infections.

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Sprache(n): eng - English
 Datum: 2012
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1007/978-1-61779-965-5_3
PMID: 22821591
BibTex Citekey: Albrecht2012f
Anderer: Local-ID: 9FC57E3E169AAD3CC1257AD9003CFBCA-Albrecht2012f
 Art des Abschluß: -

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Titel: Bioinformatics and Drug Discovery
Genre der Quelle: Buch
 Urheber:
Larson, Richard S.1, Herausgeber
Affiliations:
1 External Organizations, ou_persistent22            
Ort, Verlag, Ausgabe: New York, NY : Humana Press
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: 33 - 53 Identifikator: ISBN: 978-1-61779-964-8
ISBN: 978-1-61779-965-5

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Titel: Methods in Molecular Biology
Genre der Quelle: Reihe
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 910 Artikelnummer: - Start- / Endseite: - Identifikator: ISSN: 1064-3745
ISSN: 1940-6029