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  Synaptic Scaling and Homeostatic Plasticity in the Mouse Visual Cortex In Vivo

Keck, T., Keller, G. B., Jacobsen, R. I., Eysel, U. T., Bonhoeffer, T., & Hübener, M. (2013). Synaptic Scaling and Homeostatic Plasticity in the Mouse Visual Cortex In Vivo. NEURON, 80(2), 327-334. doi:10.1016/j.neuron.2013.08.018.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-C26C-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-C26D-3
Genre: Journal Article

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 Creators:
Keck, Tara1, Author              
Keller, Georg B.1, Author              
Jacobsen, R. Irene1, Author              
Eysel, Ulf T.2, Author
Bonhoeffer, Tobias1, Author              
Hübener, Mark1, Author              
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              
2external, ou_persistent22              

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Free keywords: NEURAL ACTIVITY; LONG-TERM; NATURAL VISION; SENSORY INPUT; EXPERIENCE; MICE; NEOCORTEX; RESPONSES; NEURONS; DEPRIVATION
 Abstract: Homeostatic plasticity is important to maintain a set level of activity in neuronal circuits and has been most extensively studied in cell cultures following activity blockade. It is still unclear, however, whether activity changes associated with mechanisms of homeostatic plasticity occur in vivo, for example after changes in sensory input. Here, we show that activity levels in the visual cortex are significantly decreased after sensory deprivation by retinal lesions, followed by a gradual increase in activity levels in the 48 hr after deprivation. These activity changes are associated with synaptic scaling, manifested in vitro by an increase in mEPSC amplitude and in vivo by an increase in spine size. Together, these data show that homeostatic activity changes occur in vivo in parallel with synaptic scaling.

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Language(s): eng - English
 Dates: 2013
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: NEURON
Source Genre: Journal
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Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 80 (2) Sequence Number: - Start / End Page: 327 - 334 Identifier: ISSN: 0896-6273