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  Mapping of the internal structure of human habenula with ex vivo MRI at 7T

Strotmann, B., Kögler, C., Bazin, P.-L., Weiss, M., Villringer, A., & Turner, R. (2013). Mapping of the internal structure of human habenula with ex vivo MRI at 7T. Frontiers in Human Neuroscience, 7: 878. doi:10.3389/fnhum.2013.00878.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-C28A-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-84EC-E
Genre: Journal Article

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© 2013 Strotmann, Kögler, Bazin,Weiss, Villringer and Turner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permit- ted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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 Creators:
Strotmann, Barbara1, Author              
Kögler, Carsten1, Author              
Bazin, Pierre-Louis1, Author              
Weiss, Marcel1, Author              
Villringer, Arno2, Author              
Turner, Robert1, Author              
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Human habenula; Habenular nuclei; Lateral habenula; Medial habenula; Ex vivo; MRI; 7T
 Abstract: The habenula is a small but important nucleus located next to the third ventricle in front of the pineal body. It helps to control the human reward system and is considered to play a key role in emotion, showing increased activation in major depressive disorders. Its dysfunction may underlie several neurological and psychiatric disorders. It is now possible to visualize the habenula and its anatomical subdivisions -- medial habenula (MHB) and lateral habenula (LHB) -- using MR techniques. The aim of this study is to further differentiate within human lateral habenula (LHB) using ex vivo ultra-high field MR structural imaging, to distinguish between a medial part (m-LHB) and a lateral part (l-LHB). High resolution T1w images with 0.3-mm isotropic resolution and T2*w images with 60-micrometer isotropic resolution were acquired on a 7T MR scanner and quantitative maps of T1 and T2* were calculated. Cluster analysis of image intensity was performed using the Fuzzy and Noise Tolerant Adaptive Segmentation Method (FANTASM) tool. Ultra-high resolution structural MRI of ex-vivo brain tissue at 7T provides sufficient SNR and contrast to discriminate the medial and lateral habenular nuclei. Heterogeneity was observed in the lateral habenula (LHB) nuclei, with clear distinctions between lateral and medial parts (m-LHB, l-LHB) and with the neighbouring medial habenula (MHB). Clustering analysis based on the T1 and T2* maps robustly shows 4 to 6 clusters as subcomponents of lateral and medial habenula.

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Language(s): eng - English
 Dates: 2013-09-032013-12-022013-12-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnhum.2013.00878
PMID: 24391571
PMC: PMC3870283
Other: eCollection 2013
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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Pages: - Volume / Issue: 7 Sequence Number: 878 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161