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  An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans.

Turek, M., Lewandrowski, I. L., & Bringmann, H. (2013). An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans. Current Biology, 23(22), 2215-2223. doi:10.1016/j.cub.2013.09.028.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-C6E6-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-E551-4
Genre: Journal Article

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Turek, M., Author
Lewandrowski, I. L.1, Author              
Bringmann, H.1, Author              
Affiliations:
1Research Group of Sleep and Waking, MPI for biophysical chemistry, Max Planck Society, ou_578607              

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 Abstract: Background: Sleep is an essential behavior that is found in all animals that have a nervous system. Neural activity is thought to control sleep, but little is known about the identity and the function of neural circuits underlying sleep. Lethargus is a developmentally regulated period of behavioral quiescence in C. elegans larvae that has sleep-like properties. Results: We studied sleep-like behavior in C. elegans larvae and found that it requires a highly conserved AP2 transcription factor, aptf-1, which was expressed strongly in only five interneurons in the head. Expression of aptf-1 in one of these neurons, the GABAergic neuron RIS, was required for quiescence. RIS was strongly and acutely activated at the transition from wake-like to sleep-like behavior. Optogenetic activation of aptf-1-expressing neurons ectopically induced acute behavioral quiescence in an aptf-1-dependent manner. RIS ablation caused a dramatic reduction of quiescence. RIS-dependent quiescence, however, does not require GABA but requires neuropeptide signaling. Conclusions: We conclude that RIS acts as a sleep-active, sleep-promoting neuron that requires aptf-1 to induce sleep-like behavior through neuropeptide signaling. Sleep-promoting GABAergic-peptidergic neurons have also been identified in vertebrate brains, suggesting that common circuit principles exist between sleep in vertebrates and sleep-like behavior in invertebrates.

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Language(s): eng - English
 Dates: 2013-11-18
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.cub.2013.09.028
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Title: Current Biology
Source Genre: Journal
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Pages: - Volume / Issue: 23 (22) Sequence Number: - Start / End Page: 2215 - 2223 Identifier: -