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  The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals.

Jedrusik-Bode, M. A., Studencka, M., Smolka, C., Baumann, T., Schmidt, H., Kampf, J., et al. (2013). The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals. Journal of Cell Science, 126, 5166-5177. doi:10.1242/jcs.130708.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-C701-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CBA2-2
Genre: Journal Article

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 Creators:
Jedrusik-Bode, M. A.1, Author              
Studencka, M.1, Author              
Smolka, C., Author
Baumann, T., Author
Schmidt, H., Author
Kampf, J., Author
Paap, F., Author
Martin, S., Author
Tazi, J., Author
Müller, K. M., Author
Krüger, M., Author
Braun, T., Author
Bober, E., Author
Affiliations:
1Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society, ou_persistent34              

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Free keywords: C. elegans, G3BP, SIRT6, Sirtuins, Stress, Stress granules
 Abstract: SIRT6 is a NAD+-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress.

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Language(s): eng - English
 Dates: 2013-09-062013-11-15
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1242/jcs.130708
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Title: Journal of Cell Science
Source Genre: Journal
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Pages: - Volume / Issue: 126 Sequence Number: - Start / End Page: 5166 - 5177 Identifier: -