English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis.

Kucherenko, M. M., & Shcherbata, H. (2013). Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis. Fly, 7(3), 173-183. doi:10.4161/fly.25241.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-CD2B-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CB49-C
Genre: Journal Article

Files

show Files
hide Files
:
1877802.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
1877802.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute), MBPC; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Kucherenko, M. M.1, Author              
Shcherbata, H.1, Author              
Affiliations:
1Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society, ou_578608              

Content

show
hide
Free keywords: Drosophila mushroom body, microRNA let-7, steroid hormone ecdysone, JAK/STAT cytokine signaling, temporal identity switch, differential cell adhesion
 Abstract: The generation of neuronal cell diversity is controlled by interdependent mechanisms, including cell intrinsic programs and environmental cues. During development, the astonishing variety of neurons is originated according to a precise timetable that is managed by a complex network of genes specifying individual types of neurons. Different neurons express specific sets of transcription factors, and they can be recognized by morphological characteristics and spatial localization, but, most importantly, they connect to each other and form functional units in a stereotyped fashion. This connectivity depends, mostly, on selective cell adhesion that is strictly regulated. While intrinsic factors specifying neuronal temporal identity have been extensively studied, an extrinsic temporal factor controlling neuronal temporal identity switch has not been shown. Our data demonstrate that pulses of steroid hormone act as a temporal cue to fine-tune neuronal cell differentiation. Here we also provide evidence that extrinsic JAK/STAT cytokine signaling acts as a spatial code in the process. Particularly, in Drosophila mushroom bodies, neuronal identity transition is controlled by steroid-dependent microRNAs that regulate spatially distributed cytokine-dependent signaling factors that in turn modulate cell adhesion. A new era of neuronal plasticity assessment via managing external temporal cues such as hormones and cytokines that specify individual types of neurons might open new possibilities for brain regenerative therapeutics.

Details

show
hide
Language(s): eng - English
 Dates: 2013-07-092013-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.4161/fly.25241
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Fly
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 7 (3) Sequence Number: - Start / End Page: 173 - 183 Identifier: -