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  Cell layers and neuropil: Contrast-enhanced MRI of mouse brain in vivo.

Watanabe, T., Frahm, J., & Michaelis, T. (2013). Cell layers and neuropil: Contrast-enhanced MRI of mouse brain in vivo. NMR in Biomedicine, 26(12), 1870-1878. doi:10.1002/nbm.3042.

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 Urheber:
Watanabe, T.1, Autor           
Frahm, J.1, Autor           
Michaelis, T.1, Autor           
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Schlagwörter: brain mapping; contrast media; gadolinium-DTPA; histology; intraventricular injections; manganese chloride; staining; subcutaneous injections
 Zusammenfassung: Contrast-enhanced T1- and T2-weighted MRI at 9.4 T and in-plane resolutions of 25 and 30 µm has been demonstrated to differentiate between neural tissues in mouse brain in vivo, including granule cell layers, principal cell layers, general neuropil, specialized neuropil and white matter. In T1-weighted MRI of the olfactory bulb, hippocampus and cerebellum, contrast obtained by the intracranial administration of gadopentetate dimeglumine (Gd-DTPA) reflects the extra- and intracellular spaces of gray matter in agreement with histological data. General neuropil areas are highlighted, whereas other tissues present with lower signal intensities. The induced contrast is similar to that in plain T2-weighted MRI, but offers a 16–30-fold higher contrast-to-noise ratio. Systemic administration of manganese chloride increases the signal-to-noise ratio in T1-weighted MRI to a significantly greater extent in principal cell layers and specialized neuropil than in granule cell layers, whereas gadolinium-enhanced MRI indicates no larger intracellular spaces in these tissues. Granule cell layers are enhanced no more than general neuropil by manganese, whereas gadolinium-enhanced MRI indicates significantly larger intracellular spaces in the cell layers. These discrepancies suggest that the signal increase after manganese administration reflects cellular activity which is disproportionate to the intracellular space. As a result, principal cell layers and specialized neuropil become highlighted, whereas granule cell layers, general neuropil and white matter present with lower signal intensities.

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Sprache(n): eng - English
 Datum: 2013-10-212013-12
 Publikationsstatus: Erschienen
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/nbm.3042
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Titel: NMR in Biomedicine
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 26 (12) Artikelnummer: - Start- / Endseite: 1870 - 1878 Identifikator: ISSN: 0952-3480