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  Tablet disintegration studied by high-resolution real-time magnetic resonance imaging.

Quodbach, J., Moussavi, A., Tammer, R., Frahm, J., & Kleinebudde, P. (2014). Tablet disintegration studied by high-resolution real-time magnetic resonance imaging. Journal of Pharmaceutical Sciences, 103(1), 249-255. doi:10.1002/jps.23789.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-0EFD-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CB5F-B
Genre: Journal Article

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 Creators:
Quodbach, J., Author
Moussavi, A.1, Author              
Tammer, R.1, Author              
Frahm, J.1, Author              
Kleinebudde, P., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: excipients; tableting; polymers; solid dosage form; materials science; MRI; tablet disintegration; superdisintegrants; disintegration mechanism; shape recovery
 Abstract: The present work employs recent advances in high-resolution real-time magnetic resonance imaging (MRI) to investigate the disintegration process of tablets containing disintegrants. A temporal resolution of 75 ms and a spatial resolution of 80 x 80 m with a section thickness of only 600 m were achieved. The histograms of MRI videos were quantitatively analyzed with MATLAB. The mechanisms of action of six commercially available disintegrants, the influence of relative tablet density, and the impact of disintegrant concentration were examined. Crospovidone seems to be the only disintegrant acting by a shape memory effect, whereas the others mainly swell. A higher relative density of tablets containing croscarmellose sodium leads to a more even distribution of water within the tablet matrix but hardly impacts the disintegration kinetics. Increasing the polacrilin potassium disintegrant concentration leads to a quicker and more thorough disintegration process. Real-time MRI emerges as valuable tool to visualize and investigate the process of tablet disintegration.

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Language(s): eng - English
 Dates: 2013-11-252014-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/jps.23789
 Degree: -

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Title: Journal of Pharmaceutical Sciences
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 103 (1) Sequence Number: - Start / End Page: 249 - 255 Identifier: -