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  Alignment-free phylogenetics and population genetics

Haubold, B. (2014). Alignment-free phylogenetics and population genetics. Briefings in Bioinformatics, 15(3): bbt083, pp. 407-418. doi:10.1093/bib/bbt083.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-1156-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-DC34-D
Genre: Journal Article

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Haubold_2013.pdf (Publisher version), 449KB
 
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 Creators:
Haubold, Bernhard1, Author              
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1Research Group Bioinformatics, Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445644              

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Free keywords: phylogenetics; population genetics; mutation distance; match length; suffix tree
 Abstract: Phylogenetics and population genetics are central disciplines in evolutionary biology. Both are based on comparative data, today usually DNA sequences. These have become so plentiful that alignment-free sequence comparison is of growing importance in the race between scientists and sequencing machines. In phylogenetics, efficient distance computation is the major contribution of alignment-free methods. A distance measure should reflect the number of substitutions per site, which underlies classical alignment-based phylogeny reconstruction. Alignment-free distance measures are either based on word counts or on match lengths, and I apply examples of both approaches to simulated and real data to assess their accuracy and efficiency. While phylogeny reconstruction is based on the number of substitutions, in population genetics, the distribution of mutations along a sequence is also considered. This distribution can be explored by match lengths, thus opening the prospect of alignment-free population genomics.

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Language(s): eng - English
 Dates: 2013-10-172013-07-052013-11-292014-05
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
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 Identifiers: DOI: 10.1093/bib/bbt083
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Title: Briefings in Bioinformatics
Source Genre: Journal
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Publ. Info: London : H. Stewart Publications
Pages: - Volume / Issue: 15 (3) Sequence Number: bbt083 Start / End Page: 407 - 418 Identifier: ISSN: 1467-5463
CoNE: https://pure.mpg.de/cone/journals/resource/974392606063