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  Developmental changes in brain activation and functional connectivity during response inhibition in the early childhood brain

Mehnert, J., Akhrif, A., Telkemeyer, S., Rossi, S., Schmitz, C. H., Steinbrink, J., et al. (2013). Developmental changes in brain activation and functional connectivity during response inhibition in the early childhood brain. Brain & Development, 35(10), 894-904. doi:10.1016/j.braindev.2012.11.006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-17AC-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-86D4-6
Genre: Journal Article

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 Creators:
Mehnert, Jan1, 2, 3, 4, Author              
Akhrif, Atae5, Author
Telkemeyer, Silke1, 6, 7, Author
Rossi, Sonja1, 2, Author              
Schmitz, Christoph H.1, 8, Author
Steinbrink, Jens1, 9, Author
Wartenburger, Isabell1, 6, 7, Author
Obrig, Hellmuth1, 2, 10, Author              
Neufang, Susanne5, Author
Affiliations:
1Berlin Neuroimaging Center, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Department of Machine Learning, TU Berlin, Germany, ou_persistent22              
4Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea, ou_persistent22              
5Department of Neuroradiology, TU Munich, Germany, ou_persistent22              
6Cluster Languages of Emotion, FU Berlin, Germany, ou_persistent22              
7Department of Linguistics, University of Potsdam, Germany, ou_persistent22              
8NIRx Medizintechnik GmbH, Berlin, Germany, ou_persistent22              
9Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
10Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Optical tomography; NIRS; Response inhibition; Functional connectivity; Development; Early childhood
 Abstract: Response inhibition is an attention function which develops relatively early during childhood. Behavioral data suggest that by the age of 3, children master the basic task requirements for the assessment of response inhibition but performance improves substantially until the age of 7. The neuronal mechanisms underlying these developmental processes, however, are not well understood. In this study, we examined brain activation patterns and behavioral performance of children aged between 4 and 6 years compared to adults by applying a go/no-go paradigm during near-infrared spectroscopy (NIRS) brain imaging. We furthermore applied task-independent functional connectivity measures to the imaging data to identify maturation of intrinsic neural functional networks. We found a significant group × condition related interaction in terms of inhibition-related reduced right fronto–parietal activation in children compared to adults. In contrast, motor-related activation did not differ between age groups. Functional connectivity analysis revealed that in the children’s group, short-range coherence within frontal areas was stronger, and long-range coherence between frontal and parietal areas was weaker, compared to adults. Our findings show that in children aged from 4 to 6 years fronto–parietal brain maturation plays a crucial part in the cognitive development of response inhibition.

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Language(s): eng - English
 Dates: 2012-11-032012-06-082012-11-122012-12-202013-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: BibTex Citekey: mehnert2012developmental
DOI: 10.1016/j.braindev.2012.11.006
PMID: 23265620
Other: Epub 2012
 Degree: -

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Title: Brain & Development
  Other : Brain Dev.
Source Genre: Journal
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Publ. Info: Tokyo : Elsevier
Pages: - Volume / Issue: 35 (10) Sequence Number: - Start / End Page: 894 - 904 Identifier: ISSN: 0387-7604
CoNE: https://pure.mpg.de/cone/journals/resource/954927558516