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  Noninvasive fluorescence imaging in animal models of stroke

Stemmer, N., Mehnert, J., Steinbrink, J., & Wunder, A. (2012). Noninvasive fluorescence imaging in animal models of stroke. Current Medicinal Chemistry, 19(28), 4786-4793. doi:10.2174/092986712803341494.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-170E-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-CD5F-3
Genre: Journal Article

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 Creators:
Stemmer, N.1, 2, 3, Author
Mehnert, Jan1, 2, 3, Author              
Steinbrink, J.1, 2, 3, Author
Wunder, A.1, 2, 3, Author
Affiliations:
1Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
2Small Animal Imaging Center, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department of Experimental Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Fluorescence; Absorption; Bioluminescence imaging; Cerebral ischemia; Experimental stroke; Fluorescence reflectance imaging; Fluorescencemediated tomography; Fluorochrome; Noninvasive fluorescence imaging; Noninvasive small animal imaging; Resolution; Stroke pathophysiology; Transillumination fluorescence imaging
 Abstract: Noninvasive fluorescence imaging (NFI) is a powerful tool to study physiology and pathophysiology in animal disease models. NFI has been successfully applied in a number of animal disease models including cancer, arthritis, and stroke. Furthermore, several applications in humans have been described. NFI is widely available in research laboratories because it has a number of advantages: It uses non-ionizing radiation and requires comparably simple, inexpensive instrumentation, and easy to handle. Fluorochromes can be detected with high sensitivity, and image acquisition time is relatively short. Furthermore, a plethora of fluorescent imaging agents is available including unspecific, target-specific, and activatable imaging probes. With these probes, biological processes such as inflammation, cell death or enzyme activity, and many others can be visualized in living animals. This review offers an overview of current approaches in NFI of stroke pathophysiology in animal models of cerebral ischemia. First, the instrumentation and the different types of imaging agents for NFI are described. Second, a short introduction to animal models of stroke is provided. Third, examples for NFI in animal models of stroke are given. Finally, the use of NFI in human stroke is critically discussed.

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Language(s): eng - English
 Dates: 2012-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: BibTex Citekey: stemmer2012noninvasive
DOI: 10.2174/092986712803341494
 Degree: -

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Title: Current Medicinal Chemistry
  Other : Curr. Med. Chem.
Source Genre: Journal
 Creator(s):
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Publ. Info: Schiphol, The Netherlands : Bentham Science Publishers
Pages: - Volume / Issue: 19 (28) Sequence Number: - Start / End Page: 4786 - 4793 Identifier: ISSN: 0929-8673
CoNE: https://pure.mpg.de/cone/journals/resource/954925568793