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  A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus

de Hollander, G., Keuken, M., Bazin, P.-L., Weiss, M., Neumann, J., Reimann, K., et al. (2014). A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus. Human Brain Mapping, 35(9), 4440-4449. doi:10.1002/hbm.22485.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-18D3-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7EFC-5
Genre: Journal Article

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 Creators:
de Hollander, Gilles1, Author
Keuken, Max1, 2, Author
Bazin, Pierre-Louis2, 3, Author              
Weiss, Marcel3, Author              
Neumann, Jane2, 4, Author              
Reimann, Katja3, Author              
Wähnert, Miriam3, Author              
Turner, Robert3, Author              
Forstmann, Birte U.1, Author
Schäfer, Andreas3, Author              
Affiliations:
1University of Amsterdam, Amsterdam Brain Center, Amsterdam, the Netherlands, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
4Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany, ou_persistent22              

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Free keywords: Subthalamic nucleus; Quantitative susceptibility mapping; Iron gradients; 7T; MRI; QSM
 Abstract: The subthalamic nucleus (STN) is an important node of the cortico-basal ganglia network and the main target of deep brain stimulation (DBS) in Parkinson’s disease. Histological studies have revealed an inhomogeneous iron distribution within the STN, which has been related to putative subdivisions within this nucleus. Here, we investigate the iron distribution in more detail using quantitative susceptibility mapping (QSM), a novel magnetic resonance imaging (MRI) contrast mechanism. QSM allows for detailed assessment of iron content in both in vivo and postmortem tissue. Twelve human participants and 7 postmortem brain samples containing the STN were scanned using ultra-high field 7 Tesla (T) MRI. Iron concentrations were found to be higher in the medial-inferior tip of the STN. Using quantitative methods we show that the increase of iron concentration towards the medial-inferior tip is of a gradual rather than a discrete nature.

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Language(s): eng - English
 Dates: 2014-01-292013-12-192014-01-312014-03-042014-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.22485
PMID: 24596026
Other: Epub 2014
 Degree: -

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 35 (9) Sequence Number: - Start / End Page: 4440 - 4449 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686