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  Mineralized self-assembled peptides on 3D laser-made scaffolds: a new route toward 'scaffold on scaffold' hard tissue engineering

Terzaki, K., Kalloudi, E., Mossou, E., Mitchell, E. P., Forsyth, V. T., Rosseeva, E., et al. (2013). Mineralized self-assembled peptides on 3D laser-made scaffolds: a new route toward 'scaffold on scaffold' hard tissue engineering. Biofabrication, 5(4): 045002, pp. 045002-1-045002-14. doi:10.1088/1758-5082/5/4/045002.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-1E10-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-1E11-7
Genre: Journal Article

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 Creators:
Terzaki, K., Author
Kalloudi, E., Author
Mossou, E., Author
Mitchell, E. P., Author
Forsyth, V. T., Author
Rosseeva, E.1, Author              
Simon, P.2, Author              
Vamvakaki, M., Author
Chatzinikolaidou, M., Author
Mitraki, A., Author
Farsari, M., Author
Affiliations:
1Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863404              
2Paul Simon, Chemical Metal Science, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863418              

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 Abstract: In this study, we propose a new approach to hard tissue regeneration based on the mineralization of 3D scaffolds made using lasers. To this end, we report the rational design of aspartate-containing self-assembling peptides targeted for calcium binding. We further investigate the suitability of these peptides to support cell attachment and proliferation when coupled on a hybrid organic-inorganic structurable material, and evaluate the response of pre-osteoblastic cells on functionalized 3D scaffolds and material surfaces. Our results show that the mineralized peptide, when immobilized on a hybrid photo-structurable material strongly supports cell adhesion, a proliferation increase after three and seven days in culture, and exhibits a statistically significant increase of biomineralization. We propose this strategy as a 'scaffold on scaffold' approach for hard tissue regeneration.

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Language(s): eng - English
 Dates: 2013-12-13
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 671358
ISI: 000327886100003
DOI: 10.1088/1758-5082/5/4/045002
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Title: Biofabrication
Source Genre: Journal
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Pages: - Volume / Issue: 5 (4) Sequence Number: 045002 Start / End Page: 045002-1 - 045002-14 Identifier: ISSN: 1758-5082