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  On the Function of Saccharides during the Nucleation of Calcium Carbonate-Protein Biocomposites

Duchstein, P., Kniep, R., & Zahn, D. (2013). On the Function of Saccharides during the Nucleation of Calcium Carbonate-Protein Biocomposites. Crystal Growth & Design, 13(11), 4885-4889. doi:10.1021/cg401070h.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-1E24-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-1E25-C
Genre: Journal Article

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 Creators:
Duchstein, P.1, Author              
Kniep, R.2, Author              
Zahn, D.1, Author              
Affiliations:
1Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863404              
2Rüdiger Kniep, Inorganic Chemistry, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863437              

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 Abstract: The molecular mechanism of calcium carbonate nucleation in the presence of various types of collageneous proteins is unravelled from computer simulation of ion-by-ion association steps. Single calcium ions are incorporated in the triplehelix by formation of salt bridges to carbonyl and hydroxyl groups of collagen, while single carbonate ions tend to bind laterally to the biomolecule. However, upon multiple ion association, the self-organization of the forming aggregate strongly depends on the triple-helical collagenous strand. In absence of glycosylated lysine residues, we observed that carbonate ions bind to calcium ions that are already incorporated into the triple helix and eventually cause the unfolding of the protein. On the other hand, otolin-1, a specific, collagen-like protein found in biogenic calcite-based composites such as otoconia, comprises a particularly high degree of glycosylated amino acids which avoid such "destructive" calcium carbonate contacts by providing alternative association sites more lateral to the backbone. This leads to the formation of a saccharide calcium carbonate agglomerate that does not compromise the protein's triple helix and constitutes the organic inorganic interface of the nucleating biocomposite.

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Language(s): eng - English
 Dates: 2013-11-08
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 671318
ISI: 000326775000033
DOI: 10.1021/cg401070h
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Title: Crystal Growth & Design
Source Genre: Journal
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Pages: - Volume / Issue: 13 (11) Sequence Number: - Start / End Page: 4885 - 4889 Identifier: ISSN: 1528-7483