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  Microdomains of SNARE proteins in the plasma membrane.

van den Bogaart, G., Lang, T., & Jahn, R. (2013). Microdomains of SNARE proteins in the plasma membrane. In V. Bennett (Ed.), Functional Organization of Vertebrate Plasma Membrane (pp. 183-230). Amsterdam: Elsevier.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-36FB-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CD71-D
Genre: Book Chapter

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 Creators:
van den Bogaart, G., Author
Lang, T., Author
Jahn, R.1, Author              
Affiliations:
1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              

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Free keywords: Membrane domain; Exocytosis; Plasma membrane; Membrane organization; SNARE
 Abstract: Exocytosis is catalyzed by the engagement of SNARE proteins embedded in the plasma membrane with complementary SNAREs in the membrane of trafficking vesicles undergoing exocytosis. In most cells studied so far, SNAREs are not randomly distributed across the plasma membrane but are clustered and segregated in discrete membrane domains of defined size, composition, and stability. SNARE clusters have been intensively studied for more than a decade. Different mechanisms have been proposed to be responsible for SNARE clustering such as partitioning into cholesterol-enriched lipid rafts, hydrophobic mismatch, posttranslational modifications of the SNAREs including phosphotylation and palmitoylation, electrostatic protein protein and protein lipid interactions, homotypic and heterotypic protein interactions, and anchoring to the cortical cytoskeleton. Although several of these proposed mechanisms are still controversially discussed, it is becoming apparent that independent physicochemical principles must cooperate in a synergistic manner to yield SNARE microdomains. Here, we discuss the architecture and function of SNARE domains. We also discuss the various factors influencing SNARE clustering, resulting in a model that we believe may be of general use to explain domain formation of proteins in the plasma membrane.

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Language(s): eng - English
 Dates: 2013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Functional Organization of Vertebrate Plasma Membrane
Source Genre: Book
 Creator(s):
Bennett, V., Editor
Affiliations:
-
Publ. Info: Amsterdam : Elsevier
Pages: XVI, 357 Volume / Issue: - Sequence Number: - Start / End Page: 183 - 230 Identifier: ISBN: 978-0-12-417027-8

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Title: Current Topics in Membranes
Source Genre: Series
 Creator(s):
Balaban, R., Editor
Simon, S. A., Editor
Affiliations:
-
Publ. Info: -
Pages: - Volume / Issue: 72 Sequence Number: - Start / End Page: - Identifier: -