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  Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion.

High, S., Andersen, S. S., Görlich, D., Hartmann, E., Prehn, S., Rapoport, T. A., et al. (1993). Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion. The Journal of Cell Biology, 121(4), 743-750.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-3BC7-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C502-9
Genre: Journal Article

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1922622.pdf (Publisher version), 2MB
 
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High, S., Author
Andersen, S. S., Author
Görlich, D.1, Author              
Hartmann, E., Author
Prehn, S., Author
Rapoport, T. A., Author
Dobberstein, B., Author
Affiliations:
1Department of Cellular Logistics, MPI for biophysical chemistry, Max Planck Society, ou_578574              

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 Abstract: Abstract. We have identified membrane components which are adjacent to type I and type II signal-anchor proteins during their insertion into the membrane of the ER. Using two different cross-linking approaches a 37-38-kD nonglycosylated protein, previously identified as P37 (High, S., D. G6dich, M. Wiedmann, T. A. Rapoport, and B. Dobberstein. 1991. J. Cell Biol. 113:35-44), was found adjacent to all the membrane inserted nascent chains used in this study. On the basis of immunoprecipitation, this ER protein was shown to be identical to the recently identified mammalian Sec61 protein. Thus, Sec61p is the principal cross-linking partner of both type I and type II signal-anchor proteins during their membrane insertion (this work), and of secretory proteins during their.

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Language(s): eng - English
 Dates: 1993
 Publication Status: Published in print
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Title: The Journal of Cell Biology
Source Genre: Journal
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Pages: - Volume / Issue: 121 (4) Sequence Number: - Start / End Page: 743 - 750 Identifier: -