English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Function of dendritic spines on hippocampal inhibitory neurons

Scheuss, V., & Bonhoeffer, T. (2014). Function of dendritic spines on hippocampal inhibitory neurons. Cerebral Cortex, 24(12), 3142-3153. doi:10.1093/cercor/bht171.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Scheuss, Volker1, Author              
Bonhoeffer, Tobias1, Author              
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

Content

show
hide
Free keywords: dendritic spine, GABAergic inhibitory interneuron, GAD65 mouse line, spine–dendrite coupling, structural plasticity
 Abstract: The majority of γ-aminobutyric acid (GABA)ergic interneurons have smooth dendrites with no or only few dendritic spines, but certain types of spiny GABAergic interneurons do actually contain substantial numbers of spines. The explanation for such spines has so far been purely structural: They increase the dendritic surface area and thus provide the opportunity to accommodate larger numbers of synapses. We reasoned that there may be specific functional properties for these spines and therefore, undertook to characterize interneuron spines functionally. We find a remarkable similarity to pyramidal cell spines: They receive excitatory synapses with calcium impermeable α-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors, compartmentalize biochemical signals, and display activity-dependent morphological plasticity. Nevertheless, notable differences in spine density, neck length, and spine–dendrite coupling exist. Thus, dendritic spines on inhibitory interneurons have a number of important functional properties that go substantially beyond simply expanding the dendritic surface area. It therefore seems likely that spiny and aspiny interneurons may have very different roles in neural circuit function and plasticity.

Details

show
hide
Language(s): eng - English
 Dates: 2014-12-01
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/cercor/bht171
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 24 (12) Sequence Number: - Start / End Page: 3142 - 3153 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440