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  Nuclear import of HIV‐1 intracellular reverse transcription complexes is mediated by importin 7.

Fassati, A., Görlich, D., Harrison, I., Zaytseva, I., & Mingot, J. M. (2003). Nuclear import of HIV‐1 intracellular reverse transcription complexes is mediated by importin 7. The EMBO Journal, 22(14), 3675-3685. doi:10.1093/emboj/cdg357.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-3DD0-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-095F-3
Genre: Journal Article

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 Creators:
Fassati, A., Author
Görlich, D.1, Author              
Harrison, I., Author
Zaytseva, I., Author
Mingot, J. M., Author
Affiliations:
1Department of Cellular Logistics, MPI for biophysical chemistry, Max Planck Society, ou_578574              

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 Abstract: Human immunodeficiency virus type 1 (HIV‐1), like other lentiviruses, can infect non‐dividing cells. This property depends on the active nuclear import of its intracellular reverse transcription complex (RTC). We have studied nuclear import of purified HIV‐1 RTCs in primary macrophages and found that importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the process. Nuclear import of RTCs requires, in addition, energy and the com ponents of the Ran system. Depletion of importin 7 from cultured cells by small interfering RNA inhibits HIV‐1 infection. These results provide a new insight into the molecular mechanism for HIV‐1 nuclear import and reveal potential targets for therapeutic intervention.

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Language(s): eng - English
 Dates: 2003-07-15
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1093/emboj/cdg357
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Title: The EMBO Journal
Source Genre: Journal
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Pages: - Volume / Issue: 22 (14) Sequence Number: - Start / End Page: 3675 - 3685 Identifier: -