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Abstract:
The 'pleckstrin homology' domain is an approximately 100-residue protein
module that has recently been added to the domain catalogue of
signalling proteins. For this review we have made an extensive database
search using a profile search method, and found a number of additional
proteins that may contain PH domains. The PH domain is present in many
kinases, isoforms of phospholipase C, GTPases, GTPase-activating
proteins and nucleotide-exchange factors, including such proteins as
Vav, Dbl and Bcr, and there are two PH domains in a guanine-nucleotide
releasing factor of Ras. Many PH-domain-containing proteins interact
with GTP-binding proteins. We have also identified a PH domain in
beta-adrenergic receptor kinase exactly in the region that has already
been shown to be involved in binding to the beta and gamma subunits of a
heterotrimeric G protein. This suggests that PH domains may be involved
in interactions with GTP-binding proteins.
