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  Genome-associated RNA polymerase II includes the dissociable Rpb4/7 subcomplex.

Jasiak, A. J., Hartmann, H., Karakasili, E., Kalocsay, M., Flatley, A., Kremmer, E., et al. (2008). Genome-associated RNA polymerase II includes the dissociable Rpb4/7 subcomplex. The Journal of Biological Chemistry, 283, 26423-26427. doi:10.1074/jbc.M803237200.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-7BE8-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C639-7
Genre: Journal Article

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 Creators:
Jasiak, A. J., Author
Hartmann, H., Author
Karakasili, E., Author
Kalocsay, M., Author
Flatley, A., Author
Kremmer, E., Author
Strässer, K., Author
Martin, D. E., Author
Söding, J.1, Author              
Cramer, P.2, Author              
Affiliations:
1Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              
2Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              

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 Abstract: Yeast RNA polymerase (Pol) II consists of a 10-subunit core enzyme and the Rpb4/7 subcomplex, which is dispensable for catalytic activity and dissociates in vitro. To investigate whether Rpb4/7 is an integral part of DNA-associated Pol II in vivo, we used chromatin immunoprecipitation coupled to high resolution tiling microarray analysis. We show that the genome-wide occupancy profiles for Rpb7 and the core subunit Rpb3 are essentially identical. Thus, the complete Pol II associates with DNA in vivo, consistent with functional roles of Rpb4/7 throughout the transcription cycle.

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Language(s): eng - English
 Dates: 2008-07-302008-09-26
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1074/jbc.M803237200
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Title: The Journal of Biological Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 283 Sequence Number: - Start / End Page: 26423 - 26427 Identifier: -