English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Structure of eukaryotic RNA polymerases.

Cramer, P., Armache, K. J., Baumli, S., Benkert, S., Brueckner, F., Buchen, C., et al. (2008). Structure of eukaryotic RNA polymerases. Annual Reviews of Biophysics, 37, 337-352. doi:10.1146/annurev.biophys.37.032807.130008.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-7BF0-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C52B-F
Genre: Journal Article

Files

show Files
hide Files
:
1935996.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
1935996.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute), Göttingen; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Cramer, P.1, Author              
Armache, K. J., Author
Baumli, S., Author
Benkert, S., Author
Brueckner, F., Author
Buchen, C., Author
Damsma, G. E., Author
Dengl, S., Author
Geiger, S. R., Author
Jasiak, A. J., Author
Jawhari, A., Author
Jennebach, S., Author
Kamenski, T., Author
Kettenberger, H., Author
Kuhn, C. D., Author
Lehmann, E., Author
Leike, K., Author
Sydow, J. F., Author
Vannini, A., Author
Affiliations:
1Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              

Content

show
hide
Free keywords: -
 Abstract: The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a catalog of available structural information for these three enzymes. Most structural data have been accumulated for Pol II and its functional complexes. These studies have provided insights into many aspects of the transcription mechanism, including initiation at promoter DNA, elongation of the mRNA chain, tunability of the polymerase active site, which supports RNA synthesis and cleavage, and the response of Pol II to DNA lesions. Detailed structural studies of Pol I and Pol III were reported recently and showed that the active center region and core enzymes are similar to Pol II and that strong structural differences on the surfaces account for gene class-specific functions.

Details

show
hide
Language(s): eng - English
 Dates: 2008-02-072008-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Annual Reviews of Biophysics
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 37 Sequence Number: - Start / End Page: 337 - 352 Identifier: -