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  Structure of an archaeal RNA polymerase.

Kusser, A. G., Bertero, M. G., Naji, S., Becker, T., Thomm, M., Beckmann, R., et al. (2008). Structure of an archaeal RNA polymerase. Journal of Molecular Biology, 376(2), 303-307. doi:10.1016/j.jmb.2007.08.066.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-7D05-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-3AA6-5
Genre: Journal Article

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 Creators:
Kusser, A. G., Author
Bertero, M. G., Author
Naji, S., Author
Becker, T., Author
Thomm, M., Author
Beckmann, R., Author
Cramer, P.1, Author              
Affiliations:
1Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              

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 Abstract: Related multisubunit RNA polymerases (RNAPs) carry out gene transcription in all kingdoms of life. Since structural information is limited to bacterial and eukaryotic RNAPs, we determined the cryo-electron microscopic structure of the RNAP from the thermophilic archaeon Pyrococcus furiosus at 13 Å resolution. Comparison with eukaryotic RNAP II reveals a conserved architecture, no homologues for subunits Rpb8 and Rpb9, and significant deviation in the polymerase foot, jaws, pore, and protrusion. The structural organization of the archaeal RNA polymerase serves as a reference for future structure–function analysis of the transcription mechanism and allows for evolutionary comparisons.

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Language(s): eng - English
 Dates: 2008-02-15
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.jmb.2007.08.066
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Title: Journal of Molecular Biology
Source Genre: Journal
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Pages: - Volume / Issue: 376 (2) Sequence Number: - Start / End Page: 303 - 307 Identifier: -