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  Myelin and iron concentration in the human brain: A quantitative study of MRI contrast

Stüber, C., Morawski, M., Schäfer, A., Labadie, C., Leuze, C., Streicher, M., et al. (2014). Myelin and iron concentration in the human brain: A quantitative study of MRI contrast. NeuroImage, 93(1), 95-106. doi:10.1016/j.neuroimage.2014.02.026.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-7EFE-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-82E4-8
Genre: Journal Article

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 Creators:
Stüber, Carsten1, Author              
Morawski, Markus2, 3, Author
Schäfer, Andreas1, Author              
Labadie, Christian4, 5, Author              
Leuze, Christoph1, Author              
Streicher, Markus1, Author              
Barapatre, Nirav6, Author
Reimann, Katja1, Author              
Geyer, Stefan1, Author              
Spemann, Daniel6, Author
Turner, Robert1, Author              
Wähnert, Miriam1, Author              
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
2Faculty of Medicine, Paul Flechsig Institute for Brain Research, University of Leipzig, Germany, ou_persistent22              
3Department of Neuroscience and Physiology, Upstate Medical University, State University of New York, Syracuse, NY, USA, ou_persistent22              
4Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
5Institut Lumière et Matière, Université Claude Bernard, Lyon, France, ou_persistent22              
6Faculty of Physics, Institute of Nuclear Solid State Physics, University of Leipzig, Germany, ou_persistent22              

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Free keywords: PIXE; Phosphorus; Magnetic susceptibility; Simulations
 Abstract: During the last five years ultra-high-field magnetic resonance imaging (MRI) has enabled an unprecedented view of living human brain. Brain tissue contrast in most MRI sequences is known to reflect mainly the spatial distributions of myelin and iron. These distributions have been shown to overlap significantly in many brain regions, especially in the cortex. It is of increasing interest to distinguish and identify cortical areas by their appearance in MRI, which has been shown to be feasible in vivo. Parcellation can benefit greatly from quantification of the independent contributions of iron and myelin to MRI contrast. Recent studies using susceptibility mapping claim to allow such a separation of the effects of myelin and iron in MRI. We show, using post-mortem human brain tissue, that this goal can be achieved. After MRI scanning of the block with appropriate T1 mapping and T2* weighted sequences, we section the block and apply a novel technique, proton induced X-ray emission (PIXE), to spatially map iron, phosphorus and sulfur elemental concentrations, simultaneously with 1 μm spatial resolution. Because most brain phosphorus is located in myelin phospholipids, a calibration step utilizing element maps of sulfur enables semi-quantitative ex vivo mapping of myelin concentration. Combining results for iron and myelin concentration in a linear model, we have accurately modeled MRI tissue contrasts. Conversely, iron and myelin concentrations can now be estimated from appropriate MRI measurements in post-mortem brain samples.

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Language(s): eng - English
 Dates: 2014-02-252013-03-062014-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2014.02.026
DOI: 24607447
Other: Epub 2014
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 93 (1) Sequence Number: - Start / End Page: 95 - 106 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166