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  Electroconvulsive therapy-induced brain plasticity determines therapeutic outcome in mood disorders

Dukart, J., Regen, F., Khefir, F., Colla, M., Bajbouj, M., Heuser, I., et al. (2014). Electroconvulsive therapy-induced brain plasticity determines therapeutic outcome in mood disorders. Proceedings of the National Academy of Sciences of the United States of America, 111(3), 1156-1161. doi:10.1073/pnas.1321399111.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-83DA-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7FB7-1
Genre: Journal Article

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 Creators:
Dukart, Jürgen1, 2, Author              
Regen, Francesca3, Author
Khefir, Ferath2, Author
Colla, Michael3, 4, Author
Bajbouj, Malek3, Author
Heuser, Isabella3, Author
Frackowiak, Richard S.2, Author
Draganski, Bogdan1, 2, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
4Experimental and Clinical Research Centre, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Magnetic resonance imaging; Voxel-based morphometry; Unipolar depression; Hippocampus
 Abstract: There remains much scientific, clinical, and ethical controversy concerning the use of electroconvulsive therapy (ECT) for psychiatric disorders stemming from a lack of information and knowledge about how such treatment might work, given its nonspecific and spatially unfocused nature. The mode of action of ECT has even been ascribed to a “barbaric” form of placebo effect. Here we show differential, highly specific, spatially distributed effects of ECT on regional brain structure in two populations: patients with unipolar or bipolar disorder. Unipolar and bipolar disorders respond differentially to ECT and the associated local brain-volume changes, which occur in areas previously associated with these diseases, correlate with symptom severity and the therapeutic effect. Our unique evidence shows that electrophysical therapeutic effects, although applied generally, take on regional significance through interactions with brain pathophysiology.

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Language(s): eng - English
 Dates: 2013-11-142013-12-302014-01-21
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1073/pnas.1321399111
PMID: 24379394
PMC: PMC3903198
Other: Epub 2013
 Degree: -

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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 111 (3) Sequence Number: - Start / End Page: 1156 - 1161 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230