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  Developmental changes in organization of structural brain networks

Khundrakpam, B. S., Reid, A., Brauer, J., Carbonell, F., Lewis, J., Ameis, S., et al. (2013). Developmental changes in organization of structural brain networks. Cerebral Cortex, 23(9), 2072-2085. doi:10.1093/cercor/bhs187.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-85F5-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9E72-B
Genre: Journal Article

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 Creators:
Khundrakpam, Budhachandra S.1, Author
Reid, Andrew1, Author
Brauer, Jens2, Author              
Carbonell, Felix1, Author
Lewis, John1, Author
Ameis, Stephanie3, Author
Karama, Sherif1, Author
Lee, Junki1, Author
Zhang , Chen1, Author
Das, Samir1, Author
Evans, Alan C.1, Author
Affiliations:
1McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Canada, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
3Department of Psychiatry, The Hospital for Sick Children, University of Toronto, Canada, ou_persistent22              

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Free keywords: Adolescence; Connectivity; Connector hub; Cortical thickness; Maturation
 Abstract: Recent findings from developmental neuroimaging studies suggest that the enhancement of cognitive processes during development may be the result of a fine-tuning of the structural and functional organization of brain with maturation. However, the details regarding the developmental trajectory of large-scale structural brain networks are not yet understood. Here, we used graph theory to examine developmental changes in the organization of structural brain networks in 203 normally growing children and adolescents. Structural brain networks were constructed using interregional correlations in cortical thickness for 4 age groups (early childhood: 4.8-8.4 year; late childhood: 8.5-11.3 year; early adolescence: 11.4-14.7 year; late adolescence: 14.8-18.3 year). Late childhood showed prominent changes in topological properties, specifically a significant reduction in local efficiency, modularity, and increased global efficiency, suggesting a shift of topological organization toward a more random configuration. An increase in number and span of distribution of connector hubs was found in this age group. Finally, inter-regional connectivity analysis and graph-theoretic measures indicated early maturation of primary sensorimotor regions and protracted development of higher order association and paralimbic regions. Our finding reveals a time window of plasticity occurring during late childhood which may accommodate crucial changes during puberty and the new developmental tasks that an adolescent faces.

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Language(s): eng - English
 Dates: 2012-07-102013-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhs187
PMID: 22784607
PMC: PMC3729193
Other: Epub 2012
 Degree: -

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 23 (9) Sequence Number: - Start / End Page: 2072 - 2085 Identifier: ISSN: 1047-3211
CoNE: /journals/resource/954925592440