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  RNA polymerase II structure: From core to functional complexes.

Cramer, P. (2004). RNA polymerase II structure: From core to functional complexes. Opinion in Geneticsand Development, 14(2), 218-226. doi:10.1016/j.gde.2004.01.003.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-8631-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C56F-8
Genre: Journal Article

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1940821.pdf (Publisher version), 411KB
 
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 Creators:
Cramer, P.1, Author              
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1Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              

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 Abstract: New structural studies of RNA polymerase II (Pol II) complexes mark the beginning of a detailed mechanistic analysis of the eukaryotic mRNA transcription cycle. Crystallographic models of the complete Pol II, together with new biochemical and electron microscopic data, give insights into transcription initiation. The first X-ray analysis of a Pol II complex with a transcription factor, the elongation factor TFIIS, supports the idea that the polymerase has a ‘tunable’ active site that switches between mRNA synthesis and cleavage. The new studies also show that domains of transcription factors can enter polymerase openings, to modulate function during transcription.

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Language(s): eng - English
 Dates: 2004-04
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.gde.2004.01.003
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Title: Opinion in Geneticsand Development
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Source Genre: Journal
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Publ. Info: London : Elsevier Current Trends
Pages: - Volume / Issue: 14 (2) Sequence Number: - Start / End Page: 218 - 226 Identifier: ISSN: 0959-437X
CoNE: https://pure.mpg.de/cone/journals/resource/954925578065_1