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Abstract:
In the present study we aimed to analyze the bacterial community structure of oral biofilms at different maturation stages in
young healthy adults. Oral biofilms established on membrane filters were collected from 32 human subjects after 5 different
maturation intervals (1, 3, 5, 9 and 14 days) and the respective phylogenetic diversity was analyzed by 16S rDNA amplicon
sequencing. Our analyses revealed highly diverse entire colonization profiles, spread into 8 phyla/candidate divisions and in
15 different bacterial classes. A large inter-individual difference in the subjects’ microbiota was observed, comprising 35% of
the total variance, but lacking conspicuous general temporal trends in both alpha and beta diversity. We further obtained
strong evidence that subjects can be categorized into three clusters based on three differently occurring and mutually
exclusive species clusters.
