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  The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat.

Kühnel, K., Jarchau, T., Wolf, E., Schlichting, I., Walter, U., Wittinghofer, A., et al. (2004). The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proceedings of the National Academy of Sciences of the United States of America, 101(49), 17027-17032. doi:10.1073/pnas.0403069101.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-8B1E-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-814C-D
Genre: Journal Article

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1944022.pdf (Publisher version), 606KB
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Kühnel, K.1, Author              
Jarchau, T., Author
Wolf, E., Author
Schlichting, I., Author
Walter, U., Author
Wittinghofer, A., Author
Strelkov, S. V., Author
Affiliations:
1Research Group of Autophagy, MPI for Biophysical Chemistry, Max Planck Society, ou_1933285              

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 Abstract: The vasodilator-stimulated phosphoprotein (VASP) is a key regulator of actin dynamics. We have determined the 1.3-Å resolution crystal structure of the 45-residue-long tetramerization domain (TD) from human VASP. This domain forms a right-handed α-helical coiled-coil structure with a similar degree of supercoiling as found in the widespread left-handed coiled coils with heptad repeats. The basis for the right-handed geometry of VASP TD is a 15-residue repeat in its amino acid sequence, which reveals a characteristic pattern of hydrophobic residues. Hydrophobic interactions and a network of salt bridges render VASP TD highly thermostable with a melting point of 120°C.

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Language(s): eng - English
 Dates: 2004-11-292004-12-07
 Publication Status: Published in print
 Pages: -
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 Rev. Method: Peer
 Identifiers: DOI: 10.1073/pnas.0403069101
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Title: Proceedings of the National Academy of Sciences of the United States of America
Source Genre: Journal
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Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 101 (49) Sequence Number: - Start / End Page: 17027 - 17032 Identifier: ISSN: 0027-8424
CoNE: /journals/resource/954925427230