English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-angstrom resolution.

Armache, J. P., Jarasch, A., Anger, A. M., Villa, E., Becker, T., Bhushan, S., et al. (2010). Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-angstrom resolution. Proceedings of the National Academy of Sciences of the United States of America, 107(46), 19748-19753. doi:10.1073/pnas.1009999107.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0017-93AB-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-814B-F
Genre: Journal Article

Files

show Files
hide Files
:
1944224.pdf (Publisher version), 4MB
Name:
1944224.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
1944224_Suppl.pdf (Supplementary material), 8MB
Name:
1944224_Suppl.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
http://www.pnas.org/content/107/46/19748.full (Publisher version)
Description:
-

Creators

show
hide
 Creators:
Armache, J. P.1, Author
Jarasch, A.1, Author
Anger, A. M.1, Author
Villa, E.1, Author
Becker, T.1, Author
Bhushan, S.1, Author
Jossinet, F.1, Author
Habeck, M.1, Author
Dindar, G.1, Author
Franckenberg, S.1, Author
Marquez, V.1, Author
Mielke, T.1, Author
Thomm, M.1, Author
Berninghausen, O.1, Author
Beatrix, B.1, Author
Söding, J.2, Author              
Westhof, E.1, Author
Wilson, D. N.1, Author
Beckmann, R.1, Author
Affiliations:
1external, ou_persistent22              
2Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              

Content

show
hide
Free keywords: -
 Abstract: Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution. This map, together with a 6.1-Å map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model ∼98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES–ES and r-protein–ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.

Details

show
hide
Language(s): eng - English
 Dates: 2010-11-16
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1073/pnas.1009999107
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the National Academy of Sciences of the United States of America
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 107 (46) Sequence Number: - Start / End Page: 19748 - 19753 Identifier: ISSN: 0027-8424
CoNE: /journals/resource/954925427230