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  Localization of eukaryote-specific ribosomal proteins in a 5.5-angstrom cryo-EM map of the 80S eukaryotic ribosome.

Armache, J. P., Jarasch, A., Anger, A. M., Villa, E., Becker, T., Bhushan, S., et al. (2010). Localization of eukaryote-specific ribosomal proteins in a 5.5-angstrom cryo-EM map of the 80S eukaryotic ribosome. Proceedings of the National Academy of Sciences of the United States of America, 107(46), 19754-19759. doi:10.1073/pnas.1010005107.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0017-9440-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-8148-6
Genre: Journal Article

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http://www.pnas.org/content/107/46/19754.full (Publisher version)
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 Creators:
Armache, J. P.1, Author
Jarasch, A.1, Author
Anger, A. M.1, Author
Villa, E.1, Author
Becker, T.1, Author
Bhushan, S.1, Author
Jossinet, F.1, Author
Habeck, M.1, Author
Dindar, G.1, Author
Franckenberg, S.1, Author
Marquez, V.1, Author
Mielke, T.1, Author
Thomm, M.1, Author
Berninghausen, O.1, Author
Beatrix, B.1, Author
Söding, J.2, Author              
Westhof, E.1, Author
Wilson, D. N.1, Author
Beckmann, R.1, Author
Affiliations:
1external, ou_persistent22              
2Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              

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 Abstract: Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial counterparts due in part to the presence of 80 r proteins rather than 54 in bacteria. Using cryoelectron microscopy reconstructions of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution, together with a 6.1-Å map of a translating Saccharomyces cerevisiae 80S ribosome, we have localized and modeled 74/80 (92.5%) of the ribosomal proteins, encompassing 12 archaeal/eukaryote-specific small subunit proteins as well as the complete complement of the ribosomal proteins of the eukaryotic large subunit. Near-complete atomic models of the 80S ribosome provide insights into the structure, function, and evolution of the eukaryotic translational apparatus.

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Language(s): eng - English
 Dates: 2010-11-16
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1073/pnas.1010005107
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Title: Proceedings of the National Academy of Sciences of the United States of America
Source Genre: Journal
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Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 107 (46) Sequence Number: - Start / End Page: 19754 - 19759 Identifier: ISSN: 0027-8424
CoNE: /journals/resource/954925427230