English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  HHrep: de novo protein repeat detection and the origin of TIM barrels.

Söding, J., Remmert, M., & Biegert, A. (2006). HHrep: de novo protein repeat detection and the origin of TIM barrels. Nucleic Acids Research (London), 34, W137-W142. doi:10.1093/nar/gkl130.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0017-EA55-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0027-C59E-F
Genre: Journal Article

Files

show Files
hide Files
:
1944246.pdf (Publisher version), 4MB
View   Save
File Permalink:
https://hdl.handle.net/11858/00-001M-0000-0017-EA5F-C
Name:
1944246.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-
:
1944246_Suppl.tex (Supplementary material), 5KB
View   Save
File Permalink:
https://hdl.handle.net/11858/00-001M-0000-0017-EA75-7
Name:
1944246_Suppl.tex
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/x-tex / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
http://nar.oxfordjournals.org/content/34/suppl_2/W137.full.pdf+html (Publisher version)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Söding, J.1, Author           
Remmert, M.2, Author
Biegert, A.2, Author
Affiliations:
1Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              
2external, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: HHrep is a web server for the de novo identification of repeats in protein sequences, which is based on the pairwise comparison of profile hidden Markov models (HMMs). Its main strength is its sensitivity, allowing it to detect highly divergent repeat units in protein sequences whose repeats could as yet only be detected from their structures. Examples include sequences with β-propellor fold, ferredoxin-like fold, double psi barrels or (βα)8 (TIM) barrels. We illustrate this with proteins from four superfamilies of TIM barrels by revealing a clear 4- and 8-fold symmetry, which we detect solely from their sequences. This symmetry might be the trace of an ancient origin through duplication of a βαβα or βα unit. HHrep can be accessed at http://hhrep.tuebingen.mpg.de.

Details

show
hide
Language(s): eng - English
 Dates: 2006-07-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/nar/gkl130
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nucleic Acids Research (London)
  Alternative Title :
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Oxford University Press
Pages: - Volume / Issue: 34 Sequence Number: - Start / End Page: W137 - W142 Identifier: ISSN: 0305-1048
CoNE: https://pure.mpg.de/cone/journals/resource/110992357379342